Entries by @framework

Treating cancer in A-T without exacerbating central nervous damage

Research Project information Principal researcher: Professor Mark Noble Institute: University of Rochester, New York, USA Grant award: $158,600 Project Completion Date: December 2016 Project Overview Children with A-T have an increased incidence of developing cancers, primarily leukaemia and lymphoma. These children also bear the additional risk that the mutation causing A-T makes cells more susceptible to agents that cause […]

Studying how genetic factors might reduce the severity of A-T

Research Project information Principal researcher:  Professor Steve Jackson and Dr Rimma Belotserkovskaya Institute: The Gurdon Institute, University of Cambridge Grant Awarded: £38,876 Project Completion Date: 30th September 2016 Project Overview Steve and Rimma proposed to study cells derived from an Ataxia Telangiectasia (A-T) patient with unusually mild symptoms even though the patient had complete loss of ATM (the protein affected […]

Childhood Ataxia Telangiectasia Neuroimaging Assessment Project – The Catnap Study

Research Project Information Principal researchers: Dr Rob Dineen and Professor Dorothee Auer Institute: University of Nottingham, UK Project Completion Date: August 2016 Project Overview This research project jointly funded with the A-T Children’s Project aimed to understand what happens in the brains of children who have A-T. The Nottingham based team used the latest techniques in MRI scanning […]

Developing a new model for testing drugs to treat Ataxia Telangiectasia

Research Project information Principal researcher: Professor Richard Gatti Institute: University of California, Los Angeles, USA Grant award: $129,318 (managed by Sparks) Project Completion Date: December 2015 Project Overview Professor Gatti and his colleagues are aiming to develop a class of drug called “read-through compounds” to treat A-T. These drugs target one specific class of mutation in the ATM gene (the gene that carries […]

Headley Does Bond Dinner Dance

6th February 2016 Dress to kill at this Bond themed dinner dance, with music by Rollercoaster. Enjoy a two course meal and a welcome drink, then hit the dance floor until midnight. UPDATE: This event has now passed, please contact events@actionforat.org for further events. Key information When: Saturday 6th February 2016 Where: Headley Village Hall […]

An ataxic mouse model of A-T

Research Project information Principal researcher: Professor Kamran Khodakhah and Ambika Tewari Institute: Albert Einstein College of Medicine, New York Cost: £100,000 over 18 months Start Date: March 2015 What are the researchers proposing to do? Kamran and Ambika aim to develop a mouse model of A-T which replicates the neurological symptoms of the condition such as ataxia (lack of […]

Stem cell transplantation for A-T

Research Project information Principal Researcher: Dr Ralf Schubert Institute: Goethe University Frankfurt, Germany Cost: €119,450 over 24 months Start Date: June 2015 This project aims to investigate the potential of bone marrow transplantation in children with A-T. Stem cell transplantation, using purified bone marrow cells could help children with A-T. It is a complicated process and chemotherapy is needed […]

A possible new role for ATM in maintaining healthy mitochondria

Research Project information Researchers: Professor Mike Kastan and Dr. Adam Brown Institute: Duke University, North Carolina, USA Cost: $163,992 over 24 months Start Date: March 2015 What are Mitochondria? Mitochondria are tiny compartments found within cells. They perform different and important functions to keep us healthy. They convert energy locked in food into energy that the cell can use. […]

Understanding dexamethasone action in Ataxia Telangiectasia

Research Project information Principal researcher: Professor Luciana Chessa Institute: The Sapienza University of Rome, Italy Grant award: €78,445 Start Date: January 2015 Duration: 12 months This research project in partnership with Sparks and the A-T Society is aimed at understanding how specific types of drugs called steroids, affect symptoms experienced by those who have A-T.   Summary of research project […]

Prudential Ride London-Surrey 100

30th July 2017 Now in its fifth year, this is cycling’s answer to the London Marathon. Celebrating the legacy created by the London 2012 Olympic and Paralympic Games, the Prudential Ride London-Surrey 100 starts in the Queen Elizabeth II Olympic Park, follows a 100-mile route on closed roads through the capital and into Surrey’s stunning […]

South Coast 100km Challenge

26th – 27th August 2017 Part of the 100km Challenge series, this trek takes you through some truly stunning scenery from Eastbourne, through the Seven Sisters Country Park, along the South Downs Way to the finish at Arundel. Choose your distance from the full 100km, the first or second half of the course, or the […]

Gene therapy for the treatment of Ataxia Telangiectasia

Research Project Information Principal researchers: Professor Ignacio Molina Institute: University of Granada, Spain Grant award: £80,200 – Funded in partnership with Sparks & A-T Society Project completion date: May 2015 Project Overview Ataxia Telangiectasia (A-T) is caused by a fault in a gene called ATM (Ataxia Telangiectasia Mutated). Unfortunately, no effective treatment is currently available and present medication only alleviates symptoms […]

Brighton Marathon 2018

15th April 2018 The Brighton Marathon is one of the UK’s favourite 26.2-milers. With a stunning backdrop of the sea in one of the country’s most vibrant cities, the race gets bigger and better every year. Renowned for its buzzing atmosphere and roaring crowd support, the course winds through the city streets, finishing up on […]