Entries by Sean Kelly

Understanding and correcting glucose metabolism defects in A-T

Research Project information Principal researcher: Associate Professor Vincenzo Costanzo Institute:   IFOM – The FIRC Institute of Molecular Oncology, Milan, Italy Cost: £125.820,50 over 36 months in partnership with the A-T Society (UK), AEFAT (Spain) and BrAshA-T (Australia) Start Date: 1st of April 2023 What are the researchers proposing to do? Costanzo and team will test the hypothesis that ATM […]

Digital drug prediction informed by genetic analysis of stem cell-derived mini-brains from A-T patients

Research Project information Principal researcher: Dr Sam Nayler Institute:  QIMR Berghofer Medical Research Institute, Queensland, Australia Cost: £151,690.39 over 36 months in partnership with the A-T Society (UK), AEFAT (Spain) and BrAshA-T (Australia) Start Date: 1st of December 2022 What are the researchers proposing to do? In a previous study, Dr Sam Nayler and his team performed genetic […]

Trial REadiness in Ataxia Telangiectasia (TREAT-AT)

Research Project information Principal researchers: Dr Rita Horvath and Dr Anke Hensiek Institute:  University of Cambridge, UK Cost: £250,000 over 36 months in partnership with the A-T Society (UK), AEFAT (Spain) and BrAshA-T (Australia) Start Date: 1st of January 2023 What are the researchers proposing to do? Ataxia Telangiectasia (A-T) is a devastating and untreatable inherited disease with neurological […]

Study of natural killer cells in A-T pathogenesis and their therapeutic implications

Research Project information Principal researchers: Dr Margherita Doria (right) and Dr. Maria Giovanna Desimio Institute:  Bambino Gesù Children’s Hospital, Italy Cost: £91,000 over 24 months in partnership with the A-T Society (UK), AEFAT (Spain) and BrAshA-T (Australia) Start Date: 1st of November 2022 (No-cost extension until February 2025 granted in July 2023) What are the researchers proposing […]

Brain-penetrating ATM gene therapy

Research Project information Principal researcher: Dr James Dixon Institute: University of Nottingham, UK Cost: £147,304.37 over 24 months in partnership with the AEFAT, A-T Society and BrAshA-T Start Date: 5th of September 2022 What are the researchers proposing to do? Dr James Dixon and team propose to combine gene therapy and editing to engineer an effective therapy to treat […]