Entries by Sean Kelly

Assessment of the frequencies and types of cancers in occurring in A-T patients

25th January 2021 in , , /by

Research Project information Principal researcher: Professor Malcolm Taylor Institute:  University of Birmingham Cost: £53,618.63 over 24 months Start Date: 1st of March 2021 What are the researchers proposing to do? Building on their initial pilot study in 2011, Professor Taylor and his team at the Institute of Cancer and Genomic Sciences will perform a detailed survey […]

A new function for ATM and a new theory for the clinical abnormalities in A-T

12th January 2021 in , , /by

Research Project information Principal researcher: Professor Michael Kastan Institute:  Duke University, USA Cost: £249,854 over 36 months Start Date: 1st of January 2021 What are the researchers proposing to do? A-T is caused by mutations in the ATM gene and results in progressive neurodegeneration, greater susceptibility to cancer, immune deficiencies, and other clinical manifestations. While much is known […]

The David Peake Study to test the feasibility of whole-body MRI for cancer surveillance in children and young people with Ataxia Telangiectasia

25th September 2020 in , , /by

Research Project information Principal researcher: Dr Rob Dineen Institute: University of Nottingham Cost: £100,556.59 over 24 months Start Date: 1st of October 2020 What are the researchers proposing to do?  Dr Rob Dineen and his team believe that the combination of an MRI scan of the whole body together with a blood test is a […]

Recurrent pulmonary infections and their impact on neurological decline in A-T

19th June 2020 in , , /by

Research Project information Principal researcher: Professor Margot Mayer-Proschel and Professor Michael O’Reilly Institute: University of Rochester, New York Cost: £246,691 over 36 months Start Date: 1st of July 2020 What are the researchers proposing to do? A-T is a multi-organ disease, yet neurological pathologies (one of the main problems in A-T) are for the most part studied in isolation from […]

An update from our Chief Executive

23rd March 2020 in , /by

The ever-changing situation in regards to COVID-19 is affecting each and every one of us and it’s clear we all have a very challenging time ahead. At Action for A-T, our main priority is to ensure the safety of the children and families living with Ataxia Telangiectasia, as well as our staff, volunteers and supporters. […]

Business Charity Awards 2020

19th March 2020 in /by

  We are delighted to have been shortlisted for the Third Sector Business Charity Awards 2020 under the category of best automotive and transport partnership. In 2019, the staff and customers of the automotive company BCA joined forces to raise funds for Action for A-T. BCA partnered with Action for A-T to deliver a mass […]

*The Stephen Green project for the study and treatment of DNA production defects in Ataxia Telangiectasia

6th March 2020 in , , /by

Research Project information Principal researcher: Dr Vincenzo Costanzo Institute: IFOM – The FIRC Institute of Molecular Oncology, Milan, Italy Cost: £99,936 over 36 months Project Completion Date: November 2019 *This project was made possible thanks to the funds raised by the 2016 Scumrun participants and donations made in memory of Stephen Green. Stephen was riding for Action for A-T when […]

Using new immunotherapy methods to treat lymphoma and leukaemia in A-T

24th February 2020 in , , /by

Research Project information Principal researcher: Dr Elad Jacoby Institute: Sheba Medical Centre, Israel Cost: £143,400 over 18 months Start Date: 1st of March 2020 What are the researchers proposing to do? Immunotherapy is a type of treatment for cancer which prompts the body’s own immune system to identify and destroy cancerous cells. The main players are called T-cells, which are […]

The ATeam: Producing healthcare guidance for children with A-T including the exploration and design of a home-based exercise package

28th January 2020 in , /by

Research Project information Principal researchers: Munira Khan & Dr Lisa Bunn Institute: University of Plymouth Cost: £89,862.48 over 36 months Start Date: 1st of February 2020 What are the researchers proposing to do? This project aims to provide the foundations for therapy research into ataxia telangiectasia (A-T).  A large team of parents, academics and clinicians who are interested in […]

Does irregular repair of DNA damage in Neurons and Lymphocytes cause cellular degeneration in A-T patients?

9th January 2020 in , /by

Research Project information Principal researcher: Dr Jean-Pierre De Villartay Institute: The IMAGINE Institute for Genetic Diseases, Paris Cost: £65,000 over 12 months Start Date: 1st of February 2020 (no cost extension until 30th June 2021 agreed January 2021) What are the researchers proposing to do? The ATM protein is one of the critical components necessary for the repair of […]