Entries by Sean Kelly

Using new immunotherapy methods to treat lymphoma and leukaemia in A-T

Research Project information Principal researcher: Dr Elad Jacoby Institute: Sheba Medical Centre, Israel Cost: £143,400 over 18 months Project Completion Date: 1st October 2021 Project Overview Immunotherapy is a type of treatment for cancer which prompts the body’s own immune system to identify and destroy cancerous cells. The main players are called T-cells, which are a type of […]

Development of CRISPR/Cas Genome Editing as a Treatment for Ataxia Telangiectasia

Research Project information Principal researcher: Professor Rafael Yáñez-Muñoz Institute:  Royal Holloway, University of London Cost: £200,000 over 36 months Project Completion Date: 30th June 2021 Project Overview The aim of this project was to begin early research to explore the use of genome editing technology, known as CRISPR, to look at ways to permanently repair the ATM […]

Does irregular repair of DNA damage in Neurons and Lymphocytes cause cellular degeneration in A-T patients?

Research Project information Principal researcher: Dr Jean-Pierre De Villartay Institute: The IMAGINE Institute for Genetic Diseases, Paris Cost: £57,629 over 12 months Project Completion Date: 30th June 2021 Project Overview The ATM protein is one of the critical components necessary for the repair of DNA damage in human cells. In patients with A-T, who have mutations in […]

A-T cerebellar neurodegeneration and inositol phosphate signalling

Research Project information Principal researcher: Professor Tanya Paull Institute: The University of Texas at Austin, USA Cost: £90,074 over 12 months in partnership with the A-T Society (UK), AEFAT (Spain) and BrAshA-T (Australia) Start Date: 1st of June 2021 What are the researchers proposing to do? This project builds on work that has already been carried out by […]

Further development of CRISPR/Cas Genome Editing as a Treatment for Ataxia Telangiectasia

Research Project information Principal researcher: Professor Rafael Yáñez-Muñoz Institute: Royal Holloway, University of London Cost: £40,000 over 36 months – follow on funding to explore new strategies Start Date: 12th March 2021 What are the researchers proposing to do? Following the completion of their original study, the Royal Holloway based team led by Professor Rafael Yáñez-Muñoz […]